A Machine Learning-Driven Framework for Accurate Brain Image Registration in Multimodal and Noisy Environments

Brain image registration is fundamental for medical imaging to allow the matching of images from multiple modalities, temporal sequences, and people to offer spatial correlation. This is crucial for activities such as cohort studies, intervention recommendations, and treatment monitoring, where exact alignment assures consistent analysis. Notwithstanding their importance, modern brain image registration techniques have many shortcomings, including limited resistance to noise, misalignment in multi-modality images, and costly computational expenses. These limits may impede real-time clinical environment practical implementation and provide less than optimal registration accuracy. This study addresses these issues by means of an Improved Brain Image Registration Technique Using Machine Learning Algorithms (BIRT-MLA). The proposed architecture detects significant image properties by means of convolutional neural networks (CNNs), therefore enabling feature extraction. By applying a supervised learning method, it guarantees precise alignment even in noisy and demanding imaging situations by forecasting transformation parameters. Lowering the registration error by modern optimization techniques helps to save processing time and maintain remarkable accuracy even in this respect. Using CNNs, the proposed method helps to effectively classify brain images, thereby improving diagnostic support and the usefulness of registered images for downstream operations. Improving clinical judgment and simplifying processes rely on grouping registration and categorization into a logical sequence. By means of enhanced alignment precision, resistance to picture faults, and shortened computing time compared to current approaches, experimental findings expose the advantages of the suggested technology. This development may be very useful in clinical and experimental settings, thereby supporting the accuracy and efficiency of brain picture analysis.

@article{Minu2026,
  title     = {A Machine Learning-Driven Framework for Accurate Brain Image Registration in Multimodal and Noisy Environments},
  journal   = {International Journal of Advanced Computer Science and Applications},
  volume    = {17},
  number    = {4},
  year      = {2026},
  publisher = {The Science and Information Organization},
  author    = {M. S. Minu and Mutharasu M and S. Hemamalini and Sunitha T and Mohanaprakash T A and Justindhas Y},
  doi       = {10.14569/IJACSA.2026.0170439},
  url       = {https://doi.org/10.14569/IJACSA.2026.0170439}
}