The Science and Information (SAI) Organization
  • Home
  • About Us
  • Journals
  • Conferences
  • Contact Us

Publication Links

  • IJACSA
  • Author Guidelines
  • Publication Policies
  • Digital Archiving Policy
  • Promote your Publication
  • Metadata Harvesting (OAI2)

IJACSA

  • About the Journal
  • Call for Papers
  • Editorial Board
  • Author Guidelines
  • Submit your Paper
  • Current Issue
  • Archives
  • Indexing
  • Fees/ APC
  • Reviewers
  • Apply as a Reviewer

IJARAI

  • About the Journal
  • Archives
  • Indexing & Archiving

Special Issues

  • Home
  • Archives
  • Proposals
  • Guest Editors
  • SUSAI-EE 2025
  • ICONS-BA 2025
  • IoT-BLOCK 2025

Future of Information and Communication Conference (FICC)

  • Home
  • Call for Papers
  • Submit your Paper/Poster
  • Register
  • Venue
  • Contact

Computing Conference

  • Home
  • Call for Papers
  • Submit your Paper/Poster
  • Register
  • Venue
  • Contact

Intelligent Systems Conference (IntelliSys)

  • Home
  • Call for Papers
  • Submit your Paper/Poster
  • Register
  • Venue
  • Contact

Future Technologies Conference (FTC)

  • Home
  • Call for Papers
  • Submit your Paper/Poster
  • Register
  • Venue
  • Contact
  • Home
  • Call for Papers
  • Editorial Board
  • Guidelines
  • Submit
  • Current Issue
  • Archives
  • Indexing
  • Fees
  • Reviewers
  • Subscribe

DOI: 10.14569/IJACSA.2020.0111182
PDF

Fine-Tuning Pre-Trained Convolutional Neural Networks for Women Common Cancer Classification using RNA-Seq Gene Expression

Author 1: Fadi Alharbi
Author 2: Murtada K. Elbashir
Author 3: Mohanad Mohammed
Author 4: Mohamed Elhafiz Mustafa

International Journal of Advanced Computer Science and Applications(IJACSA), Volume 11 Issue 11, 2020.

  • Abstract and Keywords
  • How to Cite this Article
  • {} BibTeX Source

Abstract: Most of the recent cancer classification methods use gene expression profile as features because it can provide very important information regarding tumor characteristics. Motivated by their success in the computer vision area now deep learning has been successfully applied to medical data because it can read non-linear patterns in a complex feature and can allow the leverage of information from unlabeled data of problems that do not belong to the problem being handled. In this paper, we implement transfer learning, which refers to the use of a model trained on one task to perform classification on another task to classify five cancer types that most commonly affect women. We used VGG16, Xception, DenseNet, and ResNet50 as base models and then added a dense layer to reflect our five-class classification problem. To avoid training over-fitting that can result in a very high training accuracy and a low cross-validation accuracy we used L2-regularization. We retrained (fine-tuned) these models using a five-fold cross-validation approach on RNA-Seq gene expression data after transforming it into 2D-image like data. We used the softmax activation function with the prediction dense layer and adam as optimizer in the model fit for all four architectures. The highest performance is obtained when fine-tuning Xception architecture, which achieved classification accuracy = 98.6%, precision = 98.6%, recall = 97.8%, and F1-score = 98% on five-fold cross-validation training and testing approach.

Keywords: Fine-tuning; RNA-Seq; gene expression

Fadi Alharbi, Murtada K. Elbashir, Mohanad Mohammed and Mohamed Elhafiz Mustafa, “Fine-Tuning Pre-Trained Convolutional Neural Networks for Women Common Cancer Classification using RNA-Seq Gene Expression” International Journal of Advanced Computer Science and Applications(IJACSA), 11(11), 2020. http://dx.doi.org/10.14569/IJACSA.2020.0111182

@article{Alharbi2020,
title = {Fine-Tuning Pre-Trained Convolutional Neural Networks for Women Common Cancer Classification using RNA-Seq Gene Expression},
journal = {International Journal of Advanced Computer Science and Applications},
doi = {10.14569/IJACSA.2020.0111182},
url = {http://dx.doi.org/10.14569/IJACSA.2020.0111182},
year = {2020},
publisher = {The Science and Information Organization},
volume = {11},
number = {11},
author = {Fadi Alharbi and Murtada K. Elbashir and Mohanad Mohammed and Mohamed Elhafiz Mustafa}
}



Copyright Statement: This is an open access article licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, even commercially as long as the original work is properly cited.

IJACSA

Upcoming Conferences

IntelliSys 2025

28-29 August 2025

  • Amsterdam, The Netherlands

Future Technologies Conference 2025

6-7 November 2025

  • Munich, Germany

Healthcare Conference 2026

21-22 May 2026

  • Amsterdam, The Netherlands

Computing Conference 2026

9-10 July 2026

  • London, United Kingdom

IntelliSys 2026

3-4 September 2026

  • Amsterdam, The Netherlands

Computer Vision Conference 2026

15-16 October 2026

  • Berlin, Germany
The Science and Information (SAI) Organization
BACK TO TOP

Computer Science Journal

  • About the Journal
  • Call for Papers
  • Submit Paper
  • Indexing

Our Conferences

  • Computing Conference
  • Intelligent Systems Conference
  • Future Technologies Conference
  • Communication Conference

Help & Support

  • Contact Us
  • About Us
  • Terms and Conditions
  • Privacy Policy

© The Science and Information (SAI) Organization Limited. All rights reserved. Registered in England and Wales. Company Number 8933205. thesai.org