The Science and Information (SAI) Organization
  • Home
  • About Us
  • Journals
  • Conferences
  • Contact Us

Publication Links

  • IJACSA
  • Author Guidelines
  • Publication Policies
  • Metadata Harvesting (OAI2)
  • Digital Archiving Policy

IJACSA

  • About the Journal
  • Call for Papers
  • Author Guidelines
  • Fees/ APC
  • Submit your Paper
  • Current Issue
  • Archives
  • Indexing
  • Editors
  • Reviewers
  • Apply as a Reviewer

IJARAI

  • About the Journal
  • Archives
  • Indexing & Archiving
  • Editorial Board

Special Issues

  • Home
  • Archives
  • Proposals
  • Guest Editors

Computing Conference 2021

  • Home
  • Call for Papers
  • Submit your Paper/Poster
  • Register
  • Venue
  • Contact

Intelligent Systems Conference (IntelliSys) 2021

  • Home
  • Call for Papers
  • Submit your Paper/Poster
  • Register
  • Venue
  • Contact

Future Technologies Conference (FTC) 2021

  • Home
  • Call for Papers
  • Submit your Paper/Poster
  • Register
  • Venue
  • Contact

Future of Information and Communication Conference (FICC) 2021

  • Home
  • Call for Papers
  • Submit your Paper/Poster
  • Register
  • Venue
  • Contact
  • Home
  • Call for Papers
  • Guidelines
  • Fees
  • Submit your Paper
  • Current Issue
  • Archives
  • Indexing
  • Editors
  • Reviewers
  • Subscribe

Article Details

Copyright Statement: This is an open access article licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, even commercially as long as the original work is properly cited.

A Data Mining Approach for the Prediction of Hepatitis C Virus protease Cleavage Sites

Author 1: Ahmed mohamed samir ali gamal eldin

Download PDF

Digital Object Identifier (DOI) : 10.14569/IJACSA.2011.021227

Article Published in International Journal of Advanced Computer Science and Applications(IJACSA), Volume 2 Issue 12, 2011.

  • Abstract and Keywords
  • How to Cite this Article
  • {} BibTeX Source

Abstract: Summary: Several papers have been published about the prediction of hepatitis C virus (HCV) polyprotein cleavage sites, using symbolic and non-symbolic machine learning techniques. The published papers achieved different Levels of prediction accuracy. the achieved results depends on the used technique and the availability of adequate and accurate HCV polyprotein sequences with known cleavage sites. We tried here to achieve more accurate prediction results, and more Informative knowledge about the HCV protein cleavage sites using Decision tree algorithm. There are several factors that can affect the overall prediction accuracy. One of the most important factors is the availably of acceptable and accurate HCV polyproteins sequences with known cleavage sites. We collected latest accurate data sets to build the prediction model. Also we collected another dataset for the model testing. Motivation: Hepatitis C virus is a global health problem affecting a significant portion of the world’s population. The World Health Organization estimated that in1999; 170 million hepatitis C virus (HCV) carriers were present worldwide, with 3 to 4 million new cases per year. Several approaches have been performed to analyze HCV life cycle to find out the important factors of the viral replication process. HCV polyprotein processing by the viral protease has a vital role in the virus replication. The prediction of HCV protease cleavage sites can help the biologists in the design of suitable viral inhibitors. Results: The ease to use and to understand of the decision tree enabled us to create simple prediction model. We used here the latest accurate viral datasets. Decision tree achieved here acceptable prediction accuracy results. Also it generated informative knowledge about the cleavage process itself. These results can help the researchers in the development of effective viral inhibitors. Using decision tree to predict HCV protein cleavage sites achieved high prediction accuracy.

Keywords: component; HCV polyprotein; decision tree; protease; decamers

Ahmed mohamed samir ali gamal eldin, “A Data Mining Approach for the Prediction of Hepatitis C Virus protease Cleavage Sites” International Journal of Advanced Computer Science and Applications(IJACSA), 2(12), 2011. http://dx.doi.org/10.14569/IJACSA.2011.021227

@article{eldin2011,
title = {A Data Mining Approach for the Prediction of Hepatitis C Virus protease Cleavage Sites},
journal = {International Journal of Advanced Computer Science and Applications},
doi = {10.14569/IJACSA.2011.021227},
url = {http://dx.doi.org/10.14569/IJACSA.2011.021227},
year = {2011},
publisher = {The Science and Information Organization},
volume = {2},
number = {12},
author = {Ahmed mohamed samir ali gamal eldin}
}


IJACSA

Upcoming Conferences

Future of Information and Communication Conference (FICC) 2021

29-30 April 2021

  • Virtual

Computing Conference 2021

15-16 July 2021

  • London, United Kingdom

IntelliSys 2021

2-3 September 2021

  • Amsterdam, The Netherlands

Future Technologies Conference (FTC) 2021

28-29 October 2021

  • Vancouver, Canada
The Science and Information (SAI) Organization
BACK TO TOP

Computer Science Journal

  • About the Journal
  • Call for Papers
  • Submit Paper
  • Indexing

Our Conferences

  • Computing Conference
  • Intelligent Systems Conference
  • Future Technologies Conference
  • Communication Conference

Help & Support

  • Contact Us
  • About Us
  • Terms and Conditions
  • Privacy Policy

© 2018 The Science and Information (SAI) Organization Limited. Registered in England and Wales. Company Number 8933205. All rights reserved. thesai.org