Paper 1: The Analysis of Anticancer Drug Sensitivity of Lung Cancer Cell Lines by using Machine Learning Clustering Techniques
Abstract: Lung cancer is the commonest type of cancer with the highest fatality rate worldwide. There is continued research that experiments on drug development for lung cancer patients by assessing their responses to chemotherapeutic treatments to select novel targets for improved therapies. This study aims to analyze the anticancer drug sensitivity in human lung cancer cell lines by using machine learning techniques. The data for this analysis is extracted from the National Cancer Institute (NCI). This experiment uses 408,291 human small molecule lung cancer cell lines to conclude. The values are drawn from describing the raw viability values for 91 human lung cancer cell lines treated with 354 different chemical compounds and 432 concentration points tested in each replicate experiments. Our analysis demonstrated the data from a considerable amount of cell lines clustered by using Simple K-means, Filtered clustering and by calculating sensitive drugs for each lung cancer cell line. Additionally, our analysis also demonstrated that the Neopeltolide, Parbendazole, Phloretin and Piperlongumine anti-drug chemical compounds were more sensitive for all 91 cell lines under different concentrations (p-value < 0.001). Our findings indicated that Simple K-means and Filtered clustering methods are completely similar to each other. The available literature on lung cancer cell line data observed a significant relationship between lung cancer and anticancer drugs. Our analysis of the reported experimental results demonstrated that some compounds are more sensitive than other compounds; Phloretin was the most sensitive compound for all lung cancer cell lines which were nearly about 59% out of 91 cell lines. Hence, our observation provides the methodology on how anticancer drug sensitivity of lung cancer cell lines can be analyzed by using machine learning techniques, such as clustering algorithms. This inquiry is a useful reference for researchers who are experimenting on drug developments for the lung cancer in the future.
Keywords: Data analysis; clustering; filtered clustering; simple k-means clustering; cancer; lung cancer; cancer cell lines; drug sensitivity